Learn all about Vitamin B5

What is Vitamin B5?

Boost energy & stress resilience with essential vitamin B5. Supports adrenal function & healthy skin. Discover the Pantothenic Acid advantage!

Benefits of Vitamin B5

  • Essential for energy production through its role in forming coenzyme A, which facilitates numerous metabolic reactions[ref]
"Pantothenic acid remains one of the less discussed but critically important B vitamins, involved in so many metabolic pathways that its effects are both profound and subtle. While outright deficiency is rare due to its widespread presence in foods, suboptimal intake may contribute to fatigue, stress intolerance, and poor skin healing - issues commonly seen in clinical practice but rarely attributed to B5 status. The research on therapeutic applications is still developing, but its fundamental role in energy metabolism and adrenal function deserves more attention."
- Dr. Deanna Minich, Functional Medicine Nutritionist and Fellow of the American College of Nutrition (source)

How to use Vitamin B5

Dosage

5mg daily for adults (Recommended Daily Allowance); therapeutic doses range from 10-500mg for specific conditions

Timing

Can be taken any time of day; absorption slightly improved when taken with food

Notes

Present in B-complex supplements; panthenol (provitamin B5) is common in topical formulations; calcium pantothenate is the form most often used in supplements

Who should take Vitamin B5?

  • Individuals with increased metabolic demands (athletes, pregnant/breastfeeding women)
  • Those with skin conditions such as acne, wounds, or irritation (often as topical panthenol)
  • People experiencing high stress levels or adrenal fatigue
  • Individuals with limited dietary variety or malabsorption conditions

How does Vitamin B5 work?

Vitamin B5 functions primarily through its incorporation into coenzyme A (CoA), a critical cofactor in over 100 metabolic reactions. In the citric acid cycle (Krebs cycle), CoA facilitates the breakdown of carbohydrates, fats, and proteins into usable energy (ATP). For fatty acid metabolism, CoA enables the synthesis, transport, and breakdown of fats. In adrenal function, CoA supports the production of steroid hormones, including stress hormones like cortisol. Topically, panthenol (the alcohol form) penetrates the skin, converting to pantothenic acid and improving hydration by binding water molecules while stimulating skin cell regeneration and wound healing.

Frequently asked questions

Natural sources of Vitamin B5

Vitamin B5 is widely distributed in both plant and animal foods, true to its name meaning 'from everywhere.' Rich dietary sources include organ meats (especially liver and kidney), egg yolks, salmon, avocados, mushrooms, sweet potatoes, lentils, and broccoli. Whole grains contain significant amounts, though processing can remove up to 75% of the vitamin. Sunflower seeds, chicken, milk, and yoghurt also provide reasonable amounts. Cooking losses are minimal as pantothenic acid is stable to heat, though it can be lost in food processing that removes the bran and germ from grains or through leaching into cooking water.

Potential side effects & risks

Warnings

No known toxicity at reasonable doses; safety during pregnancy established only at recommended intake levels; those with haemophilia should use high doses cautiously due to theoretical effect on blood clotting

Side effects

Generally well-tolerated even at high doses; occasional digestive upset, diarrhoea, or nausea reported with doses above 1,000mg daily

Interactions

No significant drug interactions documented; theoretically may compete with biotin absorption at very high doses; may enhance effects of some cholinergic medications