Learn all about SAM-e
What is SAM-e?
Lift mood & ease joint discomfort with pharmaceutical-grade SAM-e. Supports neurotransmitter production & liver detoxification. Feel renewed!
Benefits of SAM-e
"SAM-e represents one of the most fascinating supplements in integrated medicine due to its multiple mechanisms of action. What makes it unique is that it addresses several seemingly unrelated conditions - mood, joint health, and liver function - because these all depend on methylation chemistry. Its well-documented efficacy in double-blind trials for depression and osteoarthritis makes it particularly valuable for patients seeking evidence-based natural options."
- Dr Richard Brown, MD, Associate Professor of Clinical Psychiatry, Columbia University (source)
How to use SAM-e
Dosage
400-1600mg daily, typically starting at lower doses and gradually increasing
Timing
Best taken on an empty stomach, 30 minutes before meals; often divided into multiple doses throughout the day
Notes
Enteric-coated tablets (tablets coated to survive stomach acid) recommended for optimal absorption; can take 2-4 weeks for full benefits to develop
Who should take SAM-e?
- Individuals with low mood or seasonal mood changes
- People with joint discomfort, particularly osteoarthritis
- Those with compromised liver function seeking supportive care
- Individuals with adequate B-vitamin status (particularly B12, B6, and folate)
- Adults over 40 experiencing age-related cognitive changes
How does SAM-e work?
SAM-e functions primarily as a methyl donor in processes where methyl groups are transferred throughout the body. In the brain, it helps make brain chemicals by providing needed methyl groups, while also improving cell wall flexibility. For joint health, SAM-e enhances cartilage production by stimulating production of proteoglycans (a key component of cartilage) and exhibits anti-inflammatory properties. In the liver, it contributes to glutathione (a key antioxidant) production for detox processes and supports making fats needed for healthy cell walls.
Frequently asked questions
Natural sources of SAM-e
SAM-e is synthesised in the body from methionine (an essential amino acid) and ATP (the body's energy molecule). While small amounts of SAM-e can be found in certain foods like meat and fish, dietary sources provide negligible amounts compared to what the body produces or what's available in supplement form. The body's natural production depends on adequate intake of precursors and cofactors including methionine, folate, vitamin B12, and vitamin B6.
Potential side effects & risks
Warnings
Not recommended for individuals with bipolar disorder due to potential risk of triggering manic episodes. Should be avoided during pregnancy and breastfeeding due to insufficient safety data. Those with Parkinson's disease should consult healthcare providers before use as it may reduce L-dopa effectiveness.
Side effects
Generally well-tolerated at recommended doses. Digestive symptoms including nausea, gas, or diarrhoea may occur, especially at higher doses. Anxiety, insomnia, or restlessness occasionally reported, particularly when taken later in the day.
Interactions
May interact with antidepressant medications, particularly MAOIs, SSRIs, and SNRIs, potentially causing serotonin syndrome. Can interact with tramadol, dextromethorphan, and St. John's Wort. May affect the action of Parkinson's medications.