Learn all about MSM

MSM functions primarily by providing biologically active sulfur, an essential component of numerous body functions. This sulfur helps in making strong connections (disulfide bonds) needed for the structure of tissues like cartilage, tendons, and skin. At the cellular level, MSM seems to block a key pathway (NF-κB) that turns on inflammation, reducing the production of substances that cause inflammation (like TNF-α and IL-6). It also enhances production of glutathione (the body's main natural antioxidant) - helping to neutralise harmful molecules (reactive oxygen species) and reduce cell damage. Additionally, MSM may stabilise cell walls, improve how easily things pass into cells, and help nutrients get into cells. In joint tissues specifically, it appears to protect cartilage by slowing cartilage breakdown, potentially supporting the production of building blocks for cartilage repair (glycosaminoglycans), and reducing inflammation-causing substances in the joint fluid.

MSM occurs naturally in small amounts in various foods, though cooking, processing, and storage significantly reduce levels in the typical diet. Fresh fruits and vegetables contain modest amounts, with leafy greens, tomatoes, and cruciferous vegetables like broccoli and cabbage being better sources. Some whole grains and legumes contain trace amounts. Animal proteins including milk and eggs provide small quantities. MSM is also found in small amounts in certain beverages, including coffee, tea, and beer. Interestingly, raw cow's milk contains more MSM than pasteurised milk, highlighting how processing diminishes content. The richest natural source may be certain algae and marine plants. However, it's important to note that dietary sources generally provide milligrams of MSM, while therapeutic doses used in supplements are measured in grams, making it difficult to achieve clinical effects through diet alone.