Learn all about Glucosamine
What is Glucosamine?
Support joint comfort & mobility with glucosamine. Helps maintain cartilage & may reduce age-related stiffness. Move more freely!
Benefits of Glucosamine
"While research on glucosamine has mixed results, many patients report noticeable improvements in joint comfort and function. It has an excellent safety record, making it a reasonable choice for those seeking alternatives to NSAIDs. The key is using quality products and taking them consistently for at least three months before deciding if it works for you."
- Professor Philip Conaghan, Director of the Leeds Institute of Rheumatic and Musculoskeletal Medicine and Spokesperson for Arthritis Research UK (source)
How to use Glucosamine
Dosage
Typically 1500mg daily of glucosamine sulfate or glucosamine hydrochloride. Often taken together with chondroitin (400-1200mg daily).
Timing
Can be taken once daily or split into smaller doses. Taking with food might reduce stomach upset.
Notes
Results usually take 4-8 weeks of consistent use. The sulfate form seems more effective than the hydrochloride form according to most research.
Who should take Glucosamine?
- Adults with osteoarthritis, especially knee osteoarthritis
- Older individuals concerned about maintaining joint health
- Physically active people experiencing joint stress or discomfort
- Those looking for alternatives to anti-inflammatory drugs (NSAIDs)
How does Glucosamine work?
Glucosamine acts as a building block for glycosaminoglycans and proteoglycans, essential parts of cartilage structure. It might encourage cartilage cells ('chondrocytes') to make new cartilage material, potentially slowing down breakdown. Glucosamine also seems to have mild anti-inflammatory effects by interfering with certain inflammation signals (like NF-κB), possibly reducing inflammatory substances that damage cartilage.
Frequently asked questions
Natural sources of Glucosamine
Glucosamine occurs naturally in shellfish shells (crab, lobster, shrimp) and animal cartilage, but typical diets don't contain much. Supplements usually get glucosamine from shellfish shells, although vegetarian versions made by fermentation exist. Unlike many nutrients, you get very little glucosamine from food, so supplements are the main way to increase intake.
Potential side effects & risks
Warnings
Most comes from shellfish, so not suitable for severe shellfish allergies (unless using vegetarian forms). People with diabetes should monitor blood sugar when starting. Pregnant/breastfeeding women should consult a doctor due to limited research.
Side effects
Generally well-tolerated. Some people experience mild digestive issues (nausea, heartburn, diarrhoea). Rarely causes drowsiness or headaches.
Interactions
Potential interaction with blood thinners like warfarin. May affect blood sugar control in some people with diabetes.